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-synuclein, and that is a most important ingredient of Lewy bodies, in PARK one in 1997 and parkin in PARK two in 1998, which happens to be an E3 ubiquitin ligase and leads to endoplasmic reticulum (ER) tension, suggest that dysfunction from the intracellular proteinase techniques, including ubiquitin-proteasome program or lysosomal method, which r